ENABLING ADVANCED DIAGNOSTICS
AligND System’s nanowire waveguide technology improves sensitivity to targeted cancer biomarkers up to 20X.
The underlying mechanism is the ability of nanowires of appropriate material and diameter to act like optical fibers that collect, guide and directionally emit light from fluorescent molecules bound to their surface.
This improved sensitivity has been demonstrated repeatably by our partners at Lund University’s Physics and Immunology departments.
Additional biomedical applications being explored with interested partners include:
- Single-molecule detection of DNA and RNA biomarkers in leukemic cells using complementary beacon-coated semiconductor nanowires
- High sensitivity read out of DNA with no or limited need for polymerase chain reaction (PCR) amplification
- Discovery hitherto of unidentified protein biomarkers suspected to be present in blood
- Single low abundant membrane protein detection